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Agenesis of the Corpus Callosum Symptoms and Corpus Callosum How does it work?

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The Agenesis of the Corpus Callosum (ACC) can happen on its own or as part of a variety of developmental and dysmorphic diseases. Despite the fact that afflicted patients may have minimal visible neurologic functional abnormalities,

The removal of the corpus callosum, a structure important for interhemispheric connections, has implications for information processing and language capabilities.

The author describes methods to categorise and characterise corpus callosum agenesis based on morphologic and molecular discoveries in this paper.

Agenesis of the corpus callosum (ACC) is one of various illnesses affecting the corpus callosum, which links the left and right hemispheres of the brain. The corpus callosum is missing or largely absent in ACC. A disturbance of brain cell migration during embryonic development causes it.

Arnold-Chiari malformation, Dandy-Walker syndrome, schizencephaly (clefts or deep divisions in brain tissue), and holoprosencephaly are all examples of cerebral abnormalities that can occur alone or in conjunction with ACC (failure of the forebrain to divide into lobes.)

Aicardi syndrome is a gender-specific disorder that causes significant cognitive impairment and developmental delays in girls, as well as seizures, anomalies in the vertebrae of the spine, and retinal lesions. ACC has also been linked to abnormalities in other regions of the body,

What’s Agenesis of the Corpus Callosum?

The corpus callosum is a structure in the brain that links the right and left sides. It has 200 million nerve fibers that send and receive information.


Agenesis of the corpus callosum (ACC) is a birth abnormality in which the connections between the right and left sides of a child’s brain fail to develop properly. It affects 1 to 7 out of every 4,000 live births, according to estimates.

ACC comes in a variety of forms, such as:

  • Agenesis of a portion of the corpus callosum
  • Corpus callosum hypogenesis
  • Corpus callosum hypoplasia
  • Corpus callosum dysgenesis

A kid with ACC who is born with it has a chance of surviving. It may, however, result in developmental delays, which can range from minor to severe.

ACC, for example, might impede a child’s development of motor abilities like sitting, walking, and riding a bike. It might make swallowing and eating more challenging. Children with this illness often have poor coordination as well.

In addition, a child’s expressive communication may be hampered by language and speech difficulties.

Despite the fact that ACC can cause cognitive impairment, many persons with the disorder have normal intellect.

Points to Remember

  1. Agenesis of the corpus callosum (agcc) is a condition that affects about 1 in every 4000 live births and can be detected through neuroimaging. It might be part of a larger developmental condition or appear on its own, in which case colpocephaly and probst bundles are common.
  2. Animal models have demonstrated that neuronal proliferation and specification, axonal outgrowth and pathfinding, development and signalling at the midline, target identification, and activity-dependent augmentation or pruning are all critical for callosal development.
  3. Agcc can be brought on by a number of genetic processes. Environmental variables are likely to play a role in agcc. However, the majority of agcc instances are currently unknown.
  4. The severity of behavioural and neurological damage in agcc varies, and preliminary studies suggest that additional cns structural abnormalities linked to agcc may play a role in determining outcomes.
  5. In contrast to split-brain patients, agcc patients do not experience the disconnection phenomenon. Interhemispheric transfer of primary visual information is diminished by agcc, although hemispheric transfer of fundamental conceptual information such as letters is unaffected.
  6. Deficient problem solving, language pragmatics, and social skills are common in primary agcc, all of which lead to difficulties with daily functioning, such as maintaining relationships and a job. Interhemispheric transfer deficiencies or other structural abnormalities may be linked to cognitive and social difficulties in agcc.
  7. Many neurodevelopmental and psychiatric disorders, including schizophrenia, autism, and attention deficit hyperactivity disorder, have been associated to corpus callosum deformity or dysfunction. As a result, agcc might be a useful model for studying how callosal and cortico-cortical transmission affect these illnesses.

What are some of the additional ACC symptoms?


ACC can also cause the following symptoms:

  • Seizures
  • Issues with eyesight
  • Difficulty hearing
  • Constipation on a regular basis
  • Sagging muscles
  • A high threshold for discomfort
  • Inability to sleep
  • Immaturity in the social sphere
  • Difficulty understanding the perspectives of others
  • A lack of familiarity with slang, idioms, and social signals
  • Inability to tell the difference between truth and lies
  • Unable to reason abstractly
  • Obsessive-compulsive disorder (OCD)
  • A difficulty paying attention
  • Fearfulness
  • A loss of balance

What is the Corpus Callosum, & How does it work?

The opposing half of the body is controlled by either side of the brain. Language is processed by both hemispheres.

As a result, muscular coordination and complicated information processing necessitate the collaboration of both sides of the brain. The corpus callosum serves as a link between the two hemispheres of the brain.

The corpus callosum is a ten-centimeter-long structure in the middle of the brain that resembles the letter “C.”


Between 12 and 16 weeks after conception, and around the conclusion of the first trimester of pregnancy, the corpus callosum develops in the brain.

Throughout childhood, it will continue to grow. The corpus callosum will be fully developed by the time a child reaches the age of twelve. It will then stay the same as they get older and for the rest of their lives.

The corpus callosum’s precise function remained unclear until the 1950s. Ronald Myers, a PhD student at the University of Chicago, demonstrated in 1955 that it functioned in coordination and complicated problem-solving.

What are the many forms of callosal disorders?

The sort of callosal aberration that develops is determined by the source and timing of the prenatal brain development disturbance. The corpus callosum will not develop later if it does not form during the perinatal stage.


Callosal conditions are now characterised in medical reports and by medical practitioners in a variety of ways. The most prevalent words used to characterize these conditions are listed below.

  1. Agenesis of the Corpus Callosum (acc): agenesis of the corpus callosum is a condition in which all or part of the corpus callosum is missing; this includes both full and partial acc.
  2. Agenesis of the Corpus Callosum (agcc): agenesis of the corpus callosum is a condition in which all or part of the corpus callosum is missing. This abbreviation has just lately emerged in several academic papers.
  3. (c-acc) Complete Corpus Callosum Agenesis: the corpus callosum is totally missing.
  4. (p-acc) a piece of the corpus callosum is missing in partial agenesis of the corpus callosum; most commonly, the posterior (back) portion is lacking.
  5. Hypogenesis of the corpus callosum: another name for incomplete acc is hypogenesis of the corpus callosum.
  6. Corpus Callosum Hypoplasia: The corpus callosum is present, but it is abnormally thin.
  7. Corpus Callosum Dysgenesis: The corpus callosum is there but deformed in some way; examples include p-acc and hypoplasia.


ACC does not have a defined treatment regimen. Symptoms and seizures, if they occur, are normally managed throughout treatment.

Early detection and treatment, particularly therapies that focus on left/right coordination, make associated challenges considerably more tolerable.

The greatest treatment for improving social and developmental outcomes is now early diagnosis and intervention.

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